Post-Translational Modification

PTM

Most proteins undergo post-translational modifications after translation. Examples of post-transcriptional processes include more than 9 types of reactions; hydroxylation, methylation, and glycosylation. Newly developed drugs are able to be produced by targeting processes such as phosphorylation, acetylation, and methylation. BenoBio focuses on developing drugs based on S-nitrosylation, S-glutathionylation which relate to redox reactions.

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Deamidation

Eliminylation

Disulfide bond

Proteolysis

AMPylation

ADP-Ribosylation

Glycosylation

Lipidation

S-Glutathionylation

Avicinylation (thioesterification)

S-Nitrosylation

UBL-protein Conjugation

(e.g. SUMO)

Su

Ubiquitylation

Ub
Ac

Acetylation

Methylation

Me
P

Phosphorylation

Hydroxylation

OH
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Protein Signaling

&

Drug Target Potential